Combined Therapy Using Sairei-to (TJ-114) and Camostat Mesilate for Chronic Glomerulonephritis.
10.3937/kampomed.47.405
- VernacularTitle:慢性糸球体腎炎に対するメシル酸カモスタットと柴苓湯の併用療法について
- Author:
Yuji AKIYAMA
;
Shuji OHNO
;
Toshihisa FUJIMAKI
;
Satoru ODAGIRI
;
Toshiyuki ASAOKA
;
Masahiko TANAKA
;
Teruhiko SUZUKI
;
Yutaka DOHI
- Publication Type:Journal Article
- From:Kampo Medicine
1996;47(3):405-410
- CountryJapan
- Language:Japanese
-
Abstract:
Twenty-two patients with chronic glomerulonephritis were treated with Sairei-to (7.5g/day), either alone or in combination with camostat mesilate (600mg/day), to determine the efficacy and adverse effects of these regimens. Although there was significant improvement in proteinuria (p<0.05) after 8 weeks of treatment with Sairei-to alone, this was not longlasting. Combination therapy resulted in sustained significant improvement (p<0.03; there were two dropouts). No adverse effects were seen with either regimen. The results suggest that combination therapy using Sairei-to and camostat mesilate may be a safe and efficacious method of treatment for patients with chronic glomerulonephritis.
