Role of Neutrophils in Ischemia/Reperfusion Injury during Heart Surgery.
10.4326/jjcvs.31.8
- VernacularTitle:開心術中心虚血／再潅流障害に対する好中球の関与
- Author:
Hidenori Gohra
;
Masahiko Nishida
;
Ken Hirata
;
Akihito Mikamo
;
Yoshitaka Ikeda
;
Haruhiko Okada
;
Kimikazu Hamano
;
Nobuya Zempo
;
Kensuke Esato
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
2002;31(1):8-11
- CountryJapan
- Language:Japanese
-
Abstract:
To test the hypothesis that neutrophils play a role in ischemia/reperfusion injury during heart surgery, granulocyte elastase and myeloperoxidase release from coronary circulation were measured before and after aortic cross-clamping. The production of granulocyte elastase and myeloperoxidase across the coronary circulation elevated significantly after release of aortic cross-clamp. Furthermore, the level of granulocyte elastase and myeloperoxidase released from coronary circulation demonstrated positive correlation with the duration of the aortic cross-clamp. These data indicate that neutrophils play a major role in ischemia/reperfusion injury occurring during heart surgery.
