Importance of Na+-Ca2+ Exchange System in Post-Ischemic Reperfusion Injury.
10.4326/jjcvs.21.11
- VernacularTitle:虚血心再潅流障害発生機序に関する実験的研究 Ｎａ｀＋´‐Ｃａ｀２＋´交換機構の観点から
- Author:
Naruto MATSUDA
- Publication Type:Journal Article
- Keywords:
amiloride
- From:Japanese Journal of Cardiovascular Surgery
1992;21(1):11-16
- CountryJapan
- Language:Japanese
-
Abstract:
We studied the effects of the electrolyte composition (Na+, Ca2+) and amiloride, an inhibitor of Na+-Ca2+ exchange system on the postischemic reperfusion injury of rat hearts. The observed results are as follows: (1) Post-ischemic functional recovery increases with increased extracellular Na+ concentration of the initial reperfusate. (2) The recovery of cardiac performance is improved when the extracellular Ca2+ concentration of the initial reperfusate is reduced. (3) Amiloride, administered in the initial reperfustea, ameliorates cardiac damage in a dose-dependent manner (between 10-6M and 10-4M). It is concluded that the mechanism of post-ischemic reperfusion injury is dependent on the Na+-Ca2+ exchange system.
