A Case of Disseminated Intravascular Coagulation Complicating Thoracic Aortic Aneurysm for Which Recombinant Human Soluble Thrombomodulin Was Effective
10.4326/jjcvs.41.148
- VernacularTitle:胸部大動脈瘤に合併した DIC に対し，トロンボモデュリンアルファ製剤が著効した1例
- Author:
Ken Nakamura
;
Koji Kawahito
;
Hirokuni Naganuma
;
Kei Tanaka
;
Yoko Matsumura
;
Noriyasu Kawada
;
Norimasa Haijma
;
Kazuhiro Hashimoto
- Publication Type:Journal Article
- Keywords:
recombinant human soluble thrombomodulin;
disseminated intravascular coagulation;
thoracic aortic aneurysm
- From:Japanese Journal of Cardiovascular Surgery
2012;41(3):148-151
- CountryJapan
- Language:Japanese
-
Abstract:
Chronic disseminated intravascular coagulation (DIC) complicates 5.7% of thoracic aortic aneurysm. DIC with thoracic aortic aneurysm is characterized by hyperfibrinolysis, but usually shows a stable condition in a state of compensated non-overt DIC with limited hemorrhagic symptoms. However, in some cases, hemorrhage caused by external factors may induce uncompensated overt DIC and lead to serious hemorrhagic tendencies. In the present study, we report a patient with a thoracic aortic aneurysm complicated by DIC who exhibited marked hemorrhagic tendencies. DIC remarkably improved following administration of recombinant human soluble thrombomodulin.
