Preparation and characterization of quantum dots-peptides bioconjugations and their specificity related to recognizing tumor cells.
- Author:
Min PAN
1
;
Maoquan CHU
;
Ye SUN
;
Xin SONG
;
Jian ZHU
Author Information
1. School of Life Sicence and Technology, Tongji University, Shanghai 200092, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
pathology;
Cell Line, Tumor;
Electrophoresis, Capillary;
instrumentation;
methods;
HL-60 Cells;
Humans;
Lung Neoplasms;
pathology;
Oligopeptides;
chemistry;
Peptides;
chemistry;
Peptides, Cyclic;
chemistry;
Photochemistry;
methods;
Quantum Dots;
Spectrometry, Fluorescence
- From:
Journal of Biomedical Engineering
2007;24(3):577-581
- CountryChina
- Language:Chinese
-
Abstract:
Water-soluble CdTe quantum dots synthesized in aqueous solution have been conjugated with peptide LyP-1 using N-Succinimidyl 3-[2-pyridyldithio]-propionate (SPDP) as a cross-linking reagent. Capillary electrophoresis (CE), UV-Vis absorption and photoluminescent (PL) spectra suggested that the peptide had been successfully linked to the QDs. The QDs-peptides conjugates could specifically recognize the lung adenoma cancer cells (SPCA-1), but did not recognize promyelocytic leukemia cells (HL-60).
