Tumor necrosis factor-α regulates the osteogenic differentiation of bone marrow mesenchymal stem cells in chronic periodontitis.
- VernacularTitle:慢性牙周炎中肿瘤坏死因子α对骨髓间充质干细胞成骨分化的调控作用
- Author:
Xiaoguang LI
1
;
Yizhu WANG
1
;
Bin GUO
2
Author Information
- Publication Type:Journal Article
- Keywords: bone marrow mesenchymal stem cells; chronic periodontitis; osteogenic differentiation; tumor necrosis factor-α
- MeSH: Adult; Adult Stem Cells; Bone Marrow Cells; Bone Regeneration; Cell Differentiation; Chronic Periodontitis; Hematopoietic Stem Cells; Humans; Osteogenesis; Periodontal Ligament; Periodontium; Stem Cell Transplantation; Tumor Necrosis Factor-alpha; Wound Healing
- From: West China Journal of Stomatology 2017;35(3):334-338
- CountryChina
- Language:Chinese
- Abstract: Bone marrow mesenchymal stem cells (BMSCs) and ideal adult stem cells for alveolar bone regeneration considerably help restore the structure and function of the periodontium and promote the healing of periodontal disease. Thus, BMSC features, especially the mechanism of osteogenic differentiation, has recently become a research hotspot. Tumor necrosis factor-α (TNF-α), which is the main factor in the periodontal inflammatory microenvironment, is directly related to the osteogenic differentiation of BMSCs. Exploring the TNF-α-regulated differentiation mechanism of BMSCs aids in the search for new treatment targets. Such investigation also promotes the development of stem cell therapy for periodontal diseases. This article aims to describe the potential of TNF-α in regulating the osteogenic differentiation of stem cells.
