Advances in researches on lactate dehydrogenase-C4 isozyme.
- Author:
Yong-Zhong XIONG
1
;
Feng-Hua LAN
Author Information
1. Center for Laboratory Medicine, Fuzhou General Hospital, PLA, Fuzhou, Fujian 350025, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Isoenzymes;
genetics;
immunology;
L-Lactate Dehydrogenase;
genetics;
immunology;
Male;
Mice;
Papio;
Rabbits;
Spermatozoa;
enzymology;
Transcription, Genetic;
Vaccines, Contraceptive;
immunology
- From:
National Journal of Andrology
2003;9(8):607-610
- CountryChina
- Language:Chinese
-
Abstract:
Lactate dehydrogenase-C4 isozyme has been widely studied as the sperm-specific antigen in the research of the contraceptive vaccine. Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH-C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH-C gene transcription. The strategy is to induce antibodies in the female reproductive tract against LDH-C antigens at a sufficient level to block fertilization. Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. In addition, advances are being made in researches on the male contraceptive vaccine and synthetic peptide immunocontraceptive.
