Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population.
- Author:
Xin ZHANG
1
,
2
;
Xuehua SUN
;
Zhenhua ZHOU
;
Man LI
;
Yueqiu GAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Hepatitis B, Chronic; genetics; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Suppressor of Cytokine Signaling Proteins; genetics
- From: Journal of Southern Medical University 2014;34(4):468-471
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokine- inducible src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B.
METHODSA total of 233 Chinese Han patients with chronic hepatitis B and 148 age- and sex-matched healthy controls were enrolled in this case-control study. The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic hepatitis B.
RESULTSThe distribution of SNP rs414171 allele and genotype frequencies showed no significant difference between the patients and healthy controls (P>0.05).
CONCLUSIONCISH rs414171 is not significantly associated with the susceptibility to chronic hepatitis B in Chinese Han population.
