The relationship between dyslipemia and the polymorphism of angiotensia Ⅱ type 1 receptor gene in hypertensive Kazakkans of Xinjiang
10.3321/j.issn:0253-3758.2008.10.008
- VernacularTitle:新疆哈萨克族高血压人群的血管紧张素Ⅱ1型受体基因多态性与血脂水平的相关研究
- Author:
Tao LI
1
;
Nan-Fang LI
;
Ling ZHOU
;
Xin-Ling WANG
;
Fei-Ya ZU
;
Jun WANG
;
De-Lian ZHANG
;
Ke-Ming ZHOU
Author Information
1. 新疆维吾尔自治区人民医院
- Keywords:
Hypertension;
Receptor,angiotensin;
Lipids;
Kazakans
- From:
Chinese Journal of Cardiology
2008;36(10):893-896
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between dyslipidemia and the polymorphism of angiotensin Ⅱ type 1 receptor (AT1R) gene Al166C in hypertensive Kazakans of Xinjiang ares.Methods Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the A1166C polymorphism of AT1R gene of 296 hypertensive and 198 normotensive Kazakans.Biochemical parameters were measured by autochemical emalyzer.Results (1) The TC and LDL-C levels are significantly higher in hypertension group than those in normotensive controls [TC:(4.91±1.19)mmool/L vs.(4.43±1.20) mmol/L;LDL-C:(3.36±1.01) mmol/L vs.(2.94±1.30) mmol/L,P＜0.001).(2)In hypertension group,TC and LDL-C are related to A1166C polymorphism of AT1R gene and TC and LDLC of AC carders are significantly higher than AA carriers (P＜0.05).Condnsion The dyslipidemia is related to A1166C polymorphism of AT,R gene in hypertensive Kazakans.
