Progesterone promotes the proliferation and migration of cultured breast cancer cells.
- Author:
Jia-jia ZHAO
1
,
2
;
Xin WANG
;
Zhong-jun HUO
;
Shen-qiu LUO
;
Jing-bo XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; pathology; Cadherins; metabolism; Cell Movement; drug effects; Cell Proliferation; drug effects; Female; Humans; Progesterone; pharmacology; Tumor Cells, Cultured
- From: Journal of Southern Medical University 2010;30(3):443-446
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of progesterone on the growth and migration of breast cancer cells.
METHODSMCF-7 and T-47D cells were cultured in DMEM and stimulated with 100 nmol/L progesterone for 48 h, and the cell proliferation was evaluated by MTT assay, cell migration by wound-healing assay and E-catherin expression by Western blotting.
RESULTSProgesterone stimulated the cell proliferation and migration and down-regulated the expression of E-catherin in both MCF-7 and T-47D cells.
CONCLUSIONSProgesterone stimulates the cell proliferation and migration of cultured breast cancer cells, suggesting the clinical significance of anti-progesterone therapy in breast cancer.
