Effect of levonorgestrel-releasing intrauterine system combined with GnRH analogue for treatment of large adenomyosis.
- Author:
Zheng ZHENG
1
;
Ning-ning WANG
;
Jun-hong WANG
;
Xiao-qing GAN
;
Qing-quan ZHENG
;
Pei-qi KE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Delayed-Action Preparations; administration & dosage; Drug Therapy, Combination; Endometriosis; drug therapy; Female; Gonadotropin-Releasing Hormone; analogs & derivatives; therapeutic use; Humans; Levonorgestrel; administration & dosage; Uterine Diseases; drug therapy
- From: Journal of Southern Medical University 2010;30(3):541-546
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) combined with GnRH analogue (GnRH-a) in the treatment of adenomyosis with uterine body enlargement.
METHODSTwelve women (mane age 40.3 years) with adenomyosis and uterine cavity depth over 11 cm received injections of GnRH-a every 4 weeks, and after the uterine cavity depth was reduced to below 10 cm, LNG-IUS was deployed. VAS pain score, PBAC bleeding score, uterine volume, and hemoglobin levels of the women were measured before the treatment and at 6 and 12 months after LNG-IUS placement.
RESULTSThe VAS pain score was significantly lowered at 6 and 12 month after LNG-IUS placement (P<0.05), and the PBAC bleeding score also showed significant reductions (P<0.05). The uterine volume decreased significantly at 6 and 12 months after LNG-IUS placement as compared with that before the treatment, but was significantly greater at 6 month in comparison with that at the time of LNG-IUS placement (P<0.05). Serum hemoglobin levels underwent significant increments after LNG-IUS placement (P<0.05).
CONCLUSIONLNG-IUS combined with GnRH analogue injection can be effective in the treatment of adenomyosis with dysmenorrhea and hypermenorrhea.
