The Feature of Skewing Distribution of TCR Vbeta T Cells from Peripheral Blood and Bone Marrow in Patients with AML-M(5)
- Author:
Lijian YANG
1
;
Yangqiu LI
;
Shaohua CHEN
;
Mingfang QI
;
Yuhong LU
;
Gengxin LUO
Author Information
1. Department of Hematology, Medical College, Jinan University, Guangzhou 510632, China; Deptartment of Hematology, The First Affiliated Hospitol of Medical College, Jinan University, Guangzhou 510632, China.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2000;8(3):196-198
- CountryChina
- Language:Chinese
-
Abstract:
The TCR Vbeta 24 subfamily genes were amplified in peripheral blood and bone marrow mononuclear cells from 5 cases with acute monocytic leukemia (AML-M(5)) using RT-PCR, to observe the distribution of TCR Vbeta subfamilies. The results indicated that 1 - 19 Vbeta subfamily T cells could be identified in different samples from AML-M(5) cases. The variation of distribution of TCR Vbeta subfamily T cells could be found in different individual samples. The results provided the feature of cell immune function change in skewed distribution of TCR Vbeta subfamily T cells from peripheral blood and bone marrow of patients with AML-M(5).
