Effect of chorioamnionitis on brain injury in preterm infants.
- Author:
Li-Ping XU
1
;
Rong-Na REN
;
Shao-Bo ZHU
;
Hong-Mei ZHUANG
;
Zhong-Ling HUANG
;
Hong YANG
Author Information
- Publication Type:Journal Article
- MeSH: Cerebral Hemorrhage; epidemiology; Chorioamnionitis; Diffusion Magnetic Resonance Imaging; Female; Humans; Incidence; Infant, Newborn; Infant, Premature; Leukomalacia, Periventricular; epidemiology; Male; Pregnancy
- From: Chinese Journal of Contemporary Pediatrics 2012;14(9):661-663
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between chorioamnionitis and brain injury in preterm infants.
METHODSA total of 88 preterm infants (28-34 weeks), who were born between June 2008 and June 2011, were divided into a case group (n=41) and a control group (n=47) according to whether or not they had chorioamnionitis. All the infants were examined by brain ultrasonography periodically after birth and underwent brain diffusion weighted imaging (DWI) between 3 and 7 days after birth. The two groups were compared in terms of the incidence of periventricular leukomalacia (PVL) and periventricular and intraventricular hemorrhage (PVH-IVH) by brain magnetic resonance imaging (MRI) at the corrected gestational age of 40 weeks.
RESULTSThere was statistical significance in the incidence of PVL between the case and the control groups (32% vs 6%; P<0.05), but no significant difference in the incidence of PVH-IVH between the two groups (27% vs 23%; P>0.05).
CONCLUSIONSChorioamnionitis is associated with brain injury in preterm infants, increasing the incidence of PVL but having little influence over the incidence of PVH-IVH.
