Association between promoter polymorphisms of interleukin-4 gene and allergic rhinitis risk: a meta-analysis.
10.1007/s11596-014-1275-3
- Author:
Zhi-peng LI
1
;
Li-li YIN
;
Hui WANG
;
Li-si LIU
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, 317411734@qq.com.
- Publication Type:Journal Article
- MeSH:
Gene Frequency;
Genotype;
Humans;
Interleukin-4;
blood;
genetics;
Polymorphism, Single Nucleotide;
Promoter Regions, Genetic;
genetics;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
blood;
genetics;
Risk Factors
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2014;34(3):306-313
- CountryChina
- Language:English
-
Abstract:
The relationship of interleukin-4 (IL-4) C-33T and C-590T (C-589T) gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T (C-589T)] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical software was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of -590 (-589) polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI (1.61-2.31), P=0.00]. Meta-analysis of the TT+TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI (1.13-9.25), P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI=(1.80-3.23), P=0.00]. IL-4 gene -590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of -33 might be correlated with allergic rhinitis.
