TCR-mediated signaling.
- Author:
Chun YANG
1
;
Li-ping ZHU
;
Wei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Humans; Proto-Oncogene Proteins; metabolism; Proto-Oncogene Proteins c-cbl; Receptors, Antigen, T-Cell; immunology; physiology; Signal Transduction; immunology; physiology; Ubiquitin-Protein Ligases
- From: Acta Academiae Medicinae Sinicae 2002;24(5):532-536
- CountryChina
- Language:Chinese
- Abstract: In recent years, major progress has been obtained in studying the early events in TCR-mediated signaling. c-Cb1 has been found to be a negative regulatory factor of the tyrosine kinases in ZAP-70/SyK family. The studies on LAT, SLP-76, ItK and Vav have shown their roles in the signal transduction of Ras and phospholipase Cx1 to Ca2+. Micro-glycolipid raft also plays important role in T cell activation. This minireview shows a brief introduction to the process of TCR-mediated signaling.
