Expression and clinical significance of MMP-2 and MMP-9 in B acute lymphoblastic leukemia.
10.7534/j.issn.1009-2137.2014.03.012
- Author:
Yu-Xia PAN
1
;
Lin YANG
1
;
Shu-Peng WEN
1
;
Xiao-Jun LIU
1
;
Jian-Min LUO
2
,
3
Author Information
1. Hebei Province Key Laboratory of Blood Diseases, Department of Hematology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
2. Hebei Province Key Laboratory of Blood Diseases, Department of Hematology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China. E-mail: luojm315@
3. com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Bone Marrow Cells;
metabolism;
Female;
Humans;
Male;
Matrix Metalloproteinase 2;
metabolism;
Matrix Metalloproteinase 9;
metabolism;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
metabolism;
Prognosis;
RNA, Messenger;
genetics;
Young Adult
- From:
Journal of Experimental Hematology
2014;22(3):640-643
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the expression and clinical significance of MMP-2 and MMP-9 in patients with B-acute lymphoblastic leukemia (B-ALL). The expression of MMP-2 and MMP-9 in bone marrow mononuclear cells of B-ALL patients and normal controls was detected by RT-PCR. The gelatinolytic activity was detected by zymography. The results showed that the expression of MMP-2 in de novo and relapsed B-ALL patients was markedly higher than that in normal controls (P < 0.05). The expression of MMP-9 in de novo and relapsed B-ALL patients was markedly lower than that in normal controls (P < 0.05). The expression of MMP-2 and MMP-9 in patients with extramedullary infiltration was significantly higher than that in patients without extramedullary infiltration. The incidence of extramedullary infiltration in patients with MMP-2/MMP-9 (+) was markedly higher than that in patients with MMP-2/MMP-9 (-). The expression of MMP-9 was markedly higher in high-risk patients than that in standard-risk patients (P < 0.05), but the expression of MMP-2 had no significant difference between the high-risk and standard-risk patients (P > 0.05). It is concluded that MMP-2 and MMP-9 may be secreted by B lymphoblasts and may involve in the extramedullary infiltration. MMP-9 may correlate with poor prognosis.
