Synthesis and antiviral activities of geldanamycin analog TC-GM in vitro.
- Author:
Chun-Xin LI
1
;
Guang-Zhi SHAN
;
Bo FAN
;
Pei-Zhen TAO
;
Li-Xun ZHAO
;
Jian-Dong JIANG
;
Yu-Huan LI
;
Zhuo-Rong LI
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-HIV Agents;
chemical synthesis;
chemistry;
pharmacology;
Antiviral Agents;
chemical synthesis;
chemistry;
pharmacology;
Benzoquinones;
chemical synthesis;
chemistry;
pharmacology;
Cell Line, Tumor;
Cercopithecus aethiops;
Enterovirus B, Human;
drug effects;
physiology;
HIV-1;
drug effects;
physiology;
Hep G2 Cells;
Hepatitis B virus;
drug effects;
physiology;
Herpesvirus 1, Human;
drug effects;
physiology;
Herpesvirus 2, Human;
drug effects;
physiology;
Humans;
Lactams, Macrocyclic;
chemical synthesis;
chemistry;
pharmacology;
Lamivudine;
chemical synthesis;
chemistry;
pharmacology;
Madin Darby Canine Kidney Cells;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
pathology;
virology;
Vero Cells;
Virus Replication;
drug effects
- From:
Acta Pharmaceutica Sinica
2011;46(6):683-687
- CountryChina
- Language:Chinese
-
Abstract:
In order to find antiviral compounds with novel structures, geldanamycin and lamivudine with different antiviral mechanisms were conjunctively synthesized to acquire a new compound TC-GM, and the antiviral activity of TC-GM was measured. The antiviral activity against HIV-1 was examined by p24 antigen ELISA kit. The activity against HBV was examined by dotblot. The activity against HSV and CoxB virus was examined by CPE. TC-GM exhibited broad-spectrum antiviral activities similarly like geldanamycin. TC-GM inhibited the replication of different viruses, including HIV-1, HBV, HSV 1 and 2, CoxB6. TC-GM showed more potent inhibitory activity against HIV-1 and HBV than other detected virus.
