Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan.
- VernacularTitle:四川地区汉族人群 PLEKHA7、COL11A1和 PCMTD1-ST18基因单核苷酸多态性与原发性闭角型青光眼的关联分析
- Author:
Chang TAN
1
;
Lulin HUANG
;
Zhenglin YANG
Author Information
- Publication Type:Journal Article
- MeSH: Carrier Proteins; genetics; China; ethnology; Collagen Type XI; genetics; Female; Glaucoma, Angle-Closure; genetics; Humans; Male; Polymorphism, Single Nucleotide; Protein D-Aspartate-L-Isoaspartate Methyltransferase; genetics
- From: Chinese Journal of Medical Genetics 2016;33(4):545-549
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of single nucleotide polymorphisms (SNPs) of PLEKHA7, COL11A1 and PCMTD1-ST18 genes and primary angle closure glaucoma (PACG) among ethnic Han Chinese from Sichuan Province.
METHODSIn this study, 362 subjects with PACG and 1056 age- and sex-matched healthy controls were recruited. Genotypes of 3 reported SNPs, including PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 were determined with a SNaPshot method.
RESULTSThe P values for the genotype frequencies of rs11024102, rs3753841 and rs1015213 between the patient and control groups were 0.62 (OR=1.09, 95%CI: 0.91-1.30), 0.42 (OR=1.04, 95%CI: 0.87-1.41) and 0.34 (OR=1.35, 95%CI: 0.73-2.49), respectively. And the P values for the allele frequency distributions of PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 between the two groups were 0.347, 0.698 and 0.344, respectively.
CONCLUSIONNo significant association of PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 with PACG was found among ethnic Han Chinese from Sichuan.
