Regulatory roles of non-coding RNAs in cardiomyocyte differentiation.
- Author:
Yumei WANG
1
;
Luying PENG
;
Li LI
Author Information
1. Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Shanghai 200092, China. lilirz@tongji.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Differentiation;
genetics;
Embryo, Mammalian;
physiology;
Embryonic Stem Cells;
physiology;
Epigenesis, Genetic;
genetics;
Humans;
Myocytes, Cardiac;
physiology;
RNA, Long Noncoding;
genetics
- From:
Chinese Journal of Medical Genetics
2016;33(6):875-877
- CountryChina
- Language:Chinese
-
Abstract:
Heart is the first organ to function during mammalian embryogenesis. The differentiation of embryonic stem cells (ESCs) into cardiomyocyte is complex and dynamic, which involves 4 differentiation stages including ESCs, mesoderm, cardiac precursor, and terminal cardiomyocytes. Abnormal expression of certain genes can lead to congenital heart diseases during cardiomyocyte differentiation. Epigenetic regulation plays a crucial role on the switch of gene activation and deactivation during cardiomyocyte differentiation. Non-coding RNA, particularly microRNA and long non-coding RNA, may significantly influence gene expression. Exploring the regulatory roles of non-coding RNA in cardiomyocyte differentiation may contribute to the understanding of the functions of myocardial cells and mechanism of congenital heart diseases.
