Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice.
- Author:
Mi Hwa PARK
1
;
Young Hwa NAM
;
Ji Sook HAN
Author Information
- Publication Type:Original Article
- Keywords: Anti-diabetic effects; Sargassum coreanum extract; C57BL/KsJ-db/db mice; hyperglycemia; insulin resistance
- MeSH: Animals; Blood Glucose; Glucokinase; Glucose; Glucose-6-Phosphatase; Hemoglobin A, Glycosylated; Humans; Hyperglycemia*; Hyperinsulinism; Insulin Resistance*; Insulin*; Male; Metabolism; Mice*; Phosphoenolpyruvate; Sargassum*
- From:Nutrition Research and Practice 2015;9(5):472-479
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/OBJECTIVES: The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice. MATERIALS/METHODS: For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w). RESULTS: A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice. CONCLUSIONS: These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
