Chemical constituents from herbs of Paris verticillata.
- Author:
Xianxiao HUANG
1
;
Wenyuan GAO
;
Shuli MAN
;
Juanjuan YAN
;
Yanli WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Line, Tumor; Cell Proliferation; drug effects; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacology; Magnetic Resonance Spectroscopy; Magnoliopsida; chemistry; Mice
- From: China Journal of Chinese Materia Medica 2009;34(14):1812-1815
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents in herbs of Paris verticillata.
METHODThe compounds were isolated by column chromatography with silica gel and purified by Sephadex LH-20 and RP-HPLC. The structures were identified by means of NMR analysis.
RESULTNine compounds were isolated from the EtOAc extract and the n-BuOH extract of P. verticillata. Their structures were identified as beta-sitosterol (1), stigmasterol (2), daucosterol (3), beta-ecdysterone (4), 4-hydroxymethyl-gamma-butyrolactone (5), diosgenin-3-O-alpha-L-arabinofuranosyl (1-->4)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glycopyranoside (6), pennogenin-3-O-alpha-L-arabinofuranosyl(1-->4)-beta-D-glycopyranoside (7), pennogenin-3-O-alpha-L-arabinofuranosyl (1-->4)-[alpha-L-rhamnopy-ranosyl (1-->2)]-beta-D-glycopyranoside (8), and pennogenin-3-O-alpha-L-rhamno-pyranosyl (1-->4)-alpha-L-rhamnopyranosyl (1--4)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glycopyranoside (9).
CONCLUSIONCompounds 1-9 are isolated from P. verticillata for the first time, and compounds 3, 5 are isolated from the genus Paris for the first time. The compounds 6-9 showed certain inhibition activeness of LA-795 cells, especially, the effects of compounds 6, 8 and 9 were more significant.
