Research progress on Th17 cells.
- Author:
Wei ZHANG
1
;
Fang-jun LUO
;
Jiao-jiao ZHOU
Author Information
1. College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Autoimmune Diseases;
immunology;
physiopathology;
Interleukin-17;
biosynthesis;
immunology;
Interleukin-23;
biosynthesis;
genetics;
T-Lymphocyte Subsets;
immunology;
physiology;
T-Lymphocytes, Helper-Inducer;
classification;
cytology;
immunology;
Transforming Growth Factor beta1;
biosynthesis;
genetics
- From:
Journal of Zhejiang University. Medical sciences
2007;36(6):620-625
- CountryChina
- Language:Chinese
-
Abstract:
Th17(T helper 17 cell), a newly discovered subset of T cells is associated with IL-23 and characterized by production of IL-17, the functions of which are distinct from those of Th1, Th2 and Treg subsets. The development of Th17 cells can be promoted by TGF-beta1, IL-6, and IL-23; but inhibited by IFN-gamma, IL-4 and Socs3. It is clear that Th17 cells have protective effects on body by facilitating the pro-inflammatory responses. On the other hand, the role of Th17 cells in the pathophysiology of autoimmune diseases has been described.
