Application of array comparative genomic hybridization analysis for fetuses with growth anomalies.
- VernacularTitle:微阵列比较基因组杂交在胎儿发育异常中的应用
- Author:
Lin WANG
1
,
2
;
Xiaobin WANG
;
Na CAI
;
Bin HE
;
Qiuhua WU
;
Wei LI
;
Liping ZHANG
;
Xiaoping MA
;
Rong QIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chromosome Aberrations; Comparative Genomic Hybridization; methods; Congenital Abnormalities; genetics; DNA Copy Number Variations; Female; Humans; Pregnancy; Prenatal Diagnosis; methods
- From: Chinese Journal of Medical Genetics 2017;34(5):691-694
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the genetic etiology for fetuses featuring intrauterine growth anomalies using array-based comparative genomic hybridization (aCGH).
METHODSForty-nine fetuses were enrolled in this study. Genomic DNA of the abortive tissues was analyzed with aCGH.
RESULTSFourteen (28.6%) samples were found with chromosomal aberrations, which included 8 chromosomal aneuploidies and 6 micro-aberrations (4 with known clinical pathogenecity and 2 with unknown clinical significance).
CONCLUSIONNumerical and structural chromosomal aberrations underlie a significant proportion of fetal growth anomalies. aCGH has provided an effective method for delineating their genetic cause.
