Maternal Stress and Depressive Symptoms and Infant Development at Six Months: the Mothers and Children's Environmental Health (MOCEH) Prospective Study.
10.3346/jkms.2016.31.6.843
- Author:
Soo Young BHANG
1
;
Eunhee HA
;
Hyesook PARK
;
Mina HA
;
Yun Chul HONG
;
Boong Nyun KIM
;
Soo Jeong LEE
;
Kyung Yeon LEE
;
Ja Hyeong KIM
;
Joseph JEONG
;
Kyoung Sook JEONG
;
Boeun LEE
;
Yangho KIM
Author Information
1. Department of Child and Adolescent Psychiatry, Eulji General Hospital, School of Medicine, Eulji University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Antenatal Stress;
Cadmium;
Cognitive Development;
Depression;
Lead;
Malondialdehyde;
Oxidation
- MeSH:
Adult;
Cadmium/blood;
Child Development/*physiology;
Cohort Studies;
Depression/epidemiology/*pathology;
Female;
Humans;
Infant;
Lead/blood;
Linear Models;
Male;
Malondialdehyde/blood;
Mothers/*psychology;
Prospective Studies;
*Stress, Psychological;
Surveys and Questionnaires
- From:Journal of Korean Medical Science
2016;31(6):843-851
- CountryRepublic of Korea
- Language:English
-
Abstract:
Our objective is to evaluate the relationships between prenatal maternal stress and depressive symptoms, respectively, and infant neurodevelopment at 6 months, adjusted for heavy metals and oxidative stress. This research is a part of a multi-center birth cohort study in South Korea. Information on stress and depressive symptoms was collected during the first trimester using Psychosocial Well-Being Index Short Form (PWI-SF) and Center for Epidemiological Studies Depression Scale (CES-D). The Korean Bayley Scales of Infant Development-II assessment (BSID-II), which includes the standardized mental development index (MDI) and psychomotor developmental index (PDI), and Korean Ages & Stages Questionnaires (K-ASQ) were applied to infants at six months of age. A higher index score indicates better development. Among 641 babies, 320 were female (50%). Maternal PWI ≥ 29 (vs. PWI ≤ 18) during early pregnancy was associated with a decrease in MDI scores of 5.37 points (P = 0.02) after adjusting for socioeconomic factors. Maternal CES-D ≥ 26 (vs. CES-D ≤ 10) during early pregnancy was associated with a decrease in MDI scores of 8.18 points (P = 0.01). The associations remained significant even after adjustment for lead, cadmium, and MDA levels (P < 0.05). However, no association was found between maternal PWI/CES-D and PDI score. No interaction was observed between stress and lead exposure. We found an inverse association between prenatal maternal stress and depressive symptoms, and MDI scores in 6-month-old infants after adjustment for prenatal lead exposure, which is known to affect cognitive function negatively.
