Expressions of bFGF, ET-1 and SCF in dermal papilla cells and the relation to their biological properties.
- Author:
Zhong-fa LU
1
;
Jin-jin WU
;
Rong-qing LIU
;
Bai-yu ZHONG
;
Min ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Endothelin-1; analysis; genetics; Fibroblast Growth Factor 2; analysis; genetics; Hair Follicle; chemistry; cytology; physiology; Humans; Immunohistochemistry; In Situ Hybridization; Stem Cell Factor; analysis; genetics
- From: Journal of Zhejiang University. Medical sciences 2004;33(4):296-299
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of bFGF, ET-1 and SCF in different passages of cultured dermal papilla cells (DPC), and their possible effect on biological behaviour of DPC.
METHODSThe expression of bFGF, ET-1 and SCF in different passages of cultured DPC was detected by immunocytochemistry and in situ hybridization.
RESULTThe expression of ET-1 and SCF in early passages of cultured DPC was stronger, but became negative in late passages (>6 passages). The stronger the expression of ET-1 and SCF in DPC, the higher ability of DPC to induce hair follicle regeneration.
CONCLUSIONThe expression strength of ET-1 and SCF is related to the ability of DPC inducing hair follicle regeneration.
