Preparation and release exam of magnetic chitosan nano-spheres of doxorubicin.
- Author:
Tao HAN
1
,
2
;
Qingping XIAO
;
Yuanming ZHANG
Author Information
1. Department of Chemistry, Chongqing University of Arts and Sciences, Chongqing 402160, China. dabaiht@
2. com
- Publication Type:Journal Article
- MeSH:
Chitosan;
chemistry;
Doxorubicin;
administration & dosage;
Drug Carriers;
chemical synthesis;
Drug Delivery Systems;
methods;
Magnetics;
Nanospheres;
chemistry
- From:
Journal of Biomedical Engineering
2010;27(1):86-90
- CountryChina
- Language:Chinese
-
Abstract:
Magnetic chitosan (CS) nano-spheres were prepared by the modified suspension cross-linking technique. The results demonstrated that the magnetic drug nano-spheres are mainly spherical in form with a size of 200 to 800 nm, and show good magnetic responsivity. Here, Doxorubicin was used as exam drug. Glutaraldehyde connects Doxorubicin to CS by the chemical bond (-N = C-), and the drug content is in range of 1% to 15% (w/w). The chemical bond is broken depending on pH, so pH is the important factor for the release of doxorubicin. The doxorubicin release was 22.0%, 13.4%, and 4.1% in the space of 7d, when pH was 1, 2, 4. So the nano-spheres are pH-sensitive magnetic targeting drug micro-spheres.
