Clinical efficacy of intravenous L-carnitine in patients with right-sided heart failure induced by pulmonary arterial hypertension
10.3760/cma.j.issn.0253-3758.2010.02.014
- VernacularTitle:静脉注射左卡尼汀治疗肺动脉高压并右心功能障碍疗效观察
- Author:
Xi-Qi XU
1
;
Zhi-Cheng JING
;
Xin JIANG
;
Qin-Hua ZHAO
;
Jing HE
;
Li-Zhi DAI
;
Wen-Hui WU
;
Yun LI
;
Juan YAO
Author Information
1. 同济大学附属上海市肺科医院
- Keywords:
Hypertension,pulmonary;
Ventricular function,right;
L-carnitine
- From:
Chinese Journal of Cardiology
2010;38(2):152-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate tlle efficacy of L-carnitine in patients with right-sided heart failure induced by pulmonary arterial hypertension(PAH).Methods A total of 66 pulmonary arterial hypertension patients(14 idiopathic,36 congenital heart disease associated and 16 connective-tissue disease associated PAH,WHO heart functional class Ⅲ,n=38 or IV,n=28)were enrolled in this study and divided into control group(26 cases)and L-carnitine group(40 cases).All patients received conventional treatment according to guideline for treatment of right-sided heart failure.The patients in L-carnitine group received 5 g/d L-carnitine intravenously for seven days.Six-minute walking distance,WHO heart functional class,physical examination,and serum markers were evaluated at baseline and 7 days after enrollment.Results Compared to the baseline,six-minute walking distance was significantly increased(75m vs.45 m,P＜0.05).WHO heart functional class significantly improved(impmved 2 classes in 16 patients,impmved 1 class in 13,no improved in 6,worsen in 5 vs.3,8,9,6 respectively in the control,P=0.04),BNP level significant decreased(58.16 ng/L vs.33.29 ng/L,P=0.01)and systolic blood pressure significantly increased[8.1 mm Hg vs.2.4 mm Hg(1 mm Hg=0.133 kPa),P=0.03]in Lcarnitine group compared with those in control group.No patient was withdrawn from this study for safety reasons.Conclusions L-carnitine could improve short-term exercise capacity and WHO heart functional class in right-sided heart failure patients induced by PAH.
