Expression of regulatory T cells and natural killer T cells in peripheral blood of children with Wilms tumor.
- Author:
Jing CHEN
1
;
Tao LIN
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Humans; Infant; Kidney Neoplasms; immunology; Male; Natural Killer T-Cells; immunology; T-Lymphocytes, Regulatory; immunology; Wilms Tumor; immunology
- From: Chinese Journal of Contemporary Pediatrics 2016;18(12):1222-1226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes and clinical significance of CD4CD25CD127regulatory T cells (Treg) and CD3CD16CD56natural killer T cells (NKT) in peripheral blood of children with Wilms tumor.
METHODSTwenty-one children with Wilms tumor were enrolled as the case group, and twenty-one healthy children for physical examinations were enrolled as the control group. Flow cytometry was used to detect the levels of CD4CD25CD127T cells and CD3CD16CD56T cells in peripheral blood of two groups.
RESULTSThe level of Treg cells in peripheral blood of the case group was significantly lower than in the control group (p<0.05). The level of NKT cells in peripheral blood of the case group was significantly higher than in the control group (p<0.05).
CONCLUSIONSTreg cells and NKT cells play important roles in the occurrence and development of Wilms tumor. Treg cells and NKT cells may be useful indexes for evaluating immunological function in children with Wilms tumor.
