Research progress of the anti-HIV activity of SAMHD1.
- Author:
Jun HUANG
1
;
Chao QIU
;
Xiao-Yan ZHANG
Author Information
1. Shanghai Public Health Clinical Center Affiliated to Fudan University, Institutes of Biomedical Sciences, Fudan University, Shanghai 201508, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Line;
HIV;
metabolism;
physiology;
Humans;
Monomeric GTP-Binding Proteins;
genetics;
metabolism;
SAM Domain and HD Domain-Containing Protein 1;
Viral Regulatory and Accessory Proteins;
metabolism
- From:
Chinese Journal of Virology
2012;28(4):477-481
- CountryChina
- Language:Chinese
-
Abstract:
The SAM and HD domain containing protein 1 (Sterile alpha motif domain and HD domain-containing protein 1, SAMHD1) is a putative negative regulator of the antiviral innate immune response. It can significantly increase the antiviral immune response, mediates the interferon-induced inflammatory response involved in the host foreign-virus defense system. The early studies have focused on its gene mutations associated with Aicardi-Goutières syndrome (AGS), the latest study found that SAMHD1 as a potent dGTP-stimulated triphosphohydrolase restricts HIV-1 replication by hydrolyzing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis. Auxiliary gene of HIV-2 and simian immunodeficiency virus (SIVsm / mac) encoding the Vpx protein can eliminate HIV-1 restriction. In recent years, the research on SAMHD1, mores forward rapidly this paper overviews the recent research progression related to the above fields.
