Expression and implication of cyclooxygenase-2 mRNA in prostate cancer.
- Author:
Ming-Shan YANG
1
,
2
;
Shu-Jie XIA
;
Hai-Tao LIU
;
Xiao-Wen SUN
;
Bang-Min HAN
;
Ji-Tao WU
;
Jun LU
;
Gui-Ming LING
;
Xiao-Da TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Case-Control Studies; Cyclooxygenase 2; biosynthesis; genetics; Humans; Male; Neoplasm Staging; Prognosis; Prostate; metabolism; Prostatic Neoplasms; metabolism; pathology; RNA, Messenger; genetics; Reverse Transcriptase Polymerase Chain Reaction
- From: National Journal of Andrology 2006;12(2):159-161
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between cyclooxygenase-2 (COX-2) mRNA expression and the biological behaviors of prostate carcinoma (PCa).
METHODSThe expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined. Seven normal prostate tissues were served as control.
RESULTSThe expression of COX-2 mRNA in normal tissue of 7 control cases was all negative. There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa. There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.
CONCLUSIONCOX-2 mRNA play an important role in occurrence and progression of the PCa. COX-2 is a tumor marker which may be the possible prognostic factor of PCa.
