Study on inhibitory effect of calycosin on hepatic stellate cell activation in rats by up-regulating peroxisome proliferator-activated receptor γ.
- Author:
Jian PING
;
Hong-yun CHEN
;
Yang ZHOU
;
Gao-feng CHEN
;
Lie-ming XU
;
Yang CHENG
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Proliferation;
drug effects;
Cells, Cultured;
Drugs, Chinese Herbal;
pharmacology;
Hepatic Stellate Cells;
cytology;
drug effects;
metabolism;
Isoflavones;
pharmacology;
Male;
PPAR gamma;
genetics;
metabolism;
Rats;
Rats, Sprague-Dawley;
Receptors, Cytoplasmic and Nuclear;
genetics;
metabolism;
Up-Regulation;
drug effects
- From:
China Journal of Chinese Materia Medica
2015;40(12):2383-2388
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effect of calycosin on the proliferation and activation of primary hepatic stellate cells (HSCs) in rats, and prove calycosin shows the effects through peroxisome proliferator-activated receptor γ(PPARγ) and farnesoid X receptor (FXR). The results indicated that calycosin could inhibit HSC proliferation and expressions of activation marker smooth muscle actin-α and type I collagen. With the increase in HSC activation time, FXR expression reduced, but with no notable impact from calycosin. Calycosin could up-regulate PPARγ expression and its nuclear transition in a concentration-dependent manner. Its prohibitory effect on HSC activation could be blocked by PPARγ antagonist. In conclusion, calycosin could inhibit HSC activation and proliferation, which may be related with the up-regulation of PPARγ signal pathway.
