Uncoupling protein-2 expression in granular cells and embryo development in in vitro fertilization-embryo transfer cycle.
- Author:
Zhi-hong FU
1
;
Wen-jie ZHU
;
Xue-mei LI
;
Xiu-min CHEN
;
Fu-qi XING
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aging; metabolism; Animals; Embryo Transfer; Embryonic Development; Female; Fertilization in Vitro; Gene Expression Regulation; Humans; Infertility, Female; metabolism; Ion Channels; metabolism; Juxtaglomerular Apparatus; cytology; metabolism; Mitochondrial Proteins; metabolism; Reactive Oxygen Species; metabolism; Uncoupling Protein 2; Young Adult
- From: Journal of Southern Medical University 2007;27(7):1077-1079
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the expression of uncoupling protein-2 (UCP2) in the granular cell of women undergoing in vitro fertilization (IVF) and explore its role in embryo development.
METHODSIn this prospective study, the levels of UCP2 and reactive oxygen species (ROS) were measured by the chemiluminescence method in the granular cell of 53 women.
RESULTSWomen with low UCP2 level had higher ROS level, suggesting an inverse relationship between them (r=-0.578, P<0.01), and their oocyte development was impaired. Granular cells of elder women exhibited lowered UCP2 expression.
CONCLUSIONThe granular cells increase UCP2 expression to suppress the elevation of intracellular ROS level through a feedback mechanism and therefore protect the oocytes against oxidative stress.
