Expression of vascular endothelial growth factor C and its correlation with lymph node metastasis in colorectal carcinoma.
- Author:
Tianwen XU
1
;
Daoda CHEN
;
Jianying CHEN
Author Information
1. Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
metabolism;
secondary;
Aged;
Carcinoma, Papillary;
metabolism;
secondary;
Colorectal Neoplasms;
metabolism;
pathology;
Female;
Humans;
Lymph Nodes;
pathology;
Lymphangiogenesis;
Lymphatic Metastasis;
Male;
Middle Aged;
RNA, Messenger;
biosynthesis;
genetics;
Vascular Endothelial Growth Factor C;
biosynthesis;
genetics
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(6):596-598
- CountryChina
- Language:English
-
Abstract:
To study the expression of vascular endothelial growth factor C (VEGF-C) in colorectal carcinoma and its relationship with lymph node metastasis, the expression of VEGF-C protein in colorectal carcinoma tissues obtained from 94 patients who underwent radical resection was immunohistochemically detected. Meanwhile, the expression of VEGF-C mRNA in 4 colorectal carcinoma cell lines was examined by reverse transcription polymerase chain reaction (RT-PCR). VEGF-C protein was found to be expressed in 53.2% of patients. The expression was more frequently detected in tumors with lymph node metastasis than in those without metastasis (P<0.01), and there was significant correlation between its expression and lymphatic invasion, TNM stage (P<0.01). However, no significant correlation was found between its expression and the age, gender, tumor location, depth of invasion and vascular invasion. 2 of the 4 colorectal carcinoma cell lines, including LoVo and LoVo-5FU, expressed VEGF-C mRNA. The expression of VEGF-C is closely related to lymph node metastasis, and it might take part in the tumor lymphangiogenesis.
