Expression and clinical significance of KiSS-1 and E-cadherin in gastric cardia carcinoma.
- Author:
Zhan-hui WANG
1
;
Xiao-shan FENG
;
Gong-ping WANG
;
She-gan GAO
;
Jian-qiang MI
;
Jiang-Tao SUN
;
Zhi-feng QU
;
Jing HAN
;
Luo ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Cadherins; metabolism; Cardia; pathology; Female; Humans; Kisspeptins; Male; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; metabolism; pathology; Tumor Suppressor Proteins; metabolism
- From: Chinese Journal of Gastrointestinal Surgery 2007;10(4):380-382
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and clinical significance of KiSS- 1 and E- cadherin in gastric cardia carcinoma and the correlation between the two proteins.
METHODSThe expression of KiSS- 1 and E- cadherin in 80 patients with gastric cardia carcinoma and 20 patients with normal gastric cardia epithelium was detected by immunohistochemical technique.
RESULTSThe expression of KiSS- 1 was negatively correlated with lymphatic metastasis and clinical stage (P < 0.05), but not correlated with the cancer differentiation (P < 0.05). The expression of E- cadherin was negatively correlated with lymphatic metastasis, clinical stage, and cancer differentiation (P < 0.05). Spearman test showed a positive correlation between KiSS- 1 and E- cadherin expression (r(s)=0.722, P < 0.05).
CONCLUSIONKiSS- 1 and E- cadherin may play important roles in inhibiting the invasion and metastasis of gastric cardia carcinoma.
