Discussion on influence factors, mechanism and traditional Chinese medicine pathogenesis of idiosyncratic drug-induced liver injury.
- Author:
Gang WANG
1
;
Ying LIU
1
;
Xue-Feng HOU
1
;
Jie SONG
2
;
Hui-Hui QIU
2
;
Qing-Xiang ZHONG
2
;
Xiao-Bin JIA
2
;
Fu-Jing WANG
1
;
Nan JIANG
1
;
Zhong-Cheng KE
2
;
Liang FENG
2
Author Information
- Publication Type:Journal Article
- Keywords: adverse drug reaction; idiosyncratic drug induced liver injury; influence factors; occurrence mechanism
- From: China Journal of Chinese Materia Medica 2017;42(16):3036-3043
- CountryChina
- Language:Chinese
- Abstract: Idiosyncratic drug-induced liver injury (IDILI) is a kind of unique adverse drug reaction with relative high morbidity compared with other idiosyncratic diseases. Its occurrence, however, has nothing to do with pharmacological effects and clinical dosage of drugs administered, and only a small number of susceptible individuals will suffer from it. Especially to deserve to be mentioned, the proportion of TCM-induced IDILI showed an ascending trend year by year. So in this article, the author has reviewed some facts related with TCM-induced IDILI, including the predisposing causes and occurrence mechanism, and tries to provide reference for the prevention, diagnosis and treatment of TCM-induced IDILI through the analysis of characteristics and research status of TCM-induced IDILI and exploration of the internal relationship between Chinese medicine constitution type and IDILI.
