Chemical constituents from roots of Stelleropsis tianschanica.
10.19540/j.cnki.cjcmm.20170728.005
- Author:
Dan ZHAO
1
;
Tong-Yu WU
2
;
Yong-Qiang GUAN
3
;
Guo-Xu MA
3
;
Jing ZHANG
1
;
Lei-Ling SHI
3
Author Information
1. College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China.
2. Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin 150076, China.
3. XinJiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China.
- Publication Type:Journal Article
- Keywords:
Stelleropsis tianschanica;
TR3;
chemical constituents;
daphnoretin;
pinoresinol
- From:
China Journal of Chinese Materia Medica
2017;42(17):3379-3384
- CountryChina
- Language:Chinese
-
Abstract:
The constituents from 95% ethanol extract of the roots of Stelleropsis tianschanica were purified by column chromatography techniques, leading to the isolation of 17 compounds. Their structures were elucidated by spectroscopic dataas 5'-methoxy lariciresinol(1), pinoresinol(2), daphnoretin(3), acutissimalignan B(4),(+)-secoisolariciresinol(5),(+)-epipinoresinol(6), 7-methyi-daphnoretin(7), thero-8S-7-methoxysyringylglycerol(8), 1-O-methyl-guaiacylglycerol(9), 2R-22'-ferulic acid ester-2,3-dihydroxypropyl ester(10), vesiculosin(11), 4β,5βH-guai-9,7(11)-dien-12,8-olide-1α,8α-diol(12),(-)-nortrachelogenin(13), 4α,5βH-guai-9,7(11)-dien-12,8-olide-1α,8α-diol(14), matairesinol(15), lariciresinol(16)and isolariciresinol(17). Among them, compounds 1-13 wereobtained for the first time fromthe genus Stelleropsis. Compounds 3, 7, 10-14 were tested for their activation of orphan nuclear receptor TR3 with the immunofluorescence technology in 50 μmol•L⁻¹. The results showed that compound 10 displayed moderate activity with the activity ratio of 76.38%, and the others were only about 50.0%.
