Expression of E-cadherin and beta-catenin in Bowen's disease and squamous cell carcinoma.
- Author:
Zheng-xiao LI
1
;
Zhen-hui PENG
;
Fan-pu JI
;
Jing-yi YUAN
;
Min PAN
;
Yan LIU
;
Qiong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Bowen's Disease; metabolism; pathology; Cadherins; biosynthesis; Carcinoma, Squamous Cell; metabolism; pathology; Female; Humans; Immunohistochemistry; Male; Middle Aged; Skin Neoplasms; metabolism; pathology; beta Catenin; biosynthesis
- From: Journal of Southern Medical University 2006;26(8):1245-1247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).
METHODSFifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.
RESULTNormal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.
CONCLUSIONAbnormal expression of the E-cadherin/catenin complex is common in SCC and BD.
