Apoptosis and expression of Fas/FasL in tumor infiltrating dendritic cells in human endometrioid adenocarcinoma.
- Author:
Jian-jun JIA
1
;
Zi-neng WANG
;
Ge-xiu LIU
;
Zhi-xin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; physiology; Carcinoma, Endometrioid; immunology; metabolism; pathology; Case-Control Studies; Dendritic Cells; immunology; Endometrial Neoplasms; immunology; metabolism; pathology; Fas Ligand Protein; genetics; metabolism; Female; Humans; Lymphocytes, Tumor-Infiltrating; immunology; Tumor Escape; fas Receptor; genetics; metabolism
- From: Journal of Southern Medical University 2011;31(10):1693-1696
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate apoptosis of tumor infiltrating dendritic cells (TIDC) and their expression of Fas/FasL (CD95/CD95L) in human endometrioid adenocarcinoma.
METHODSThe apoptotic rate of TIDC was measured in 45 cases of endometrioid adenocarcinoma and 20 cases of normal endometrium tissues (control) by double-label immunohistochemistry using the monoclonal antibody S-100 protein and TUNEL technique. The expressions of Fas and FasL in TIDCs were detected using double-label immunohistochemistry and imaging analysis.
RESULTSThe apoptotic rate of TIDCs in endometrioid adenocarcinoma were significantly higher than that in normal endormetrium [(13.02∓0.64)% vs (6.82∓0.53)%, P<0.05]. The expression levels of Fas in the TIDCs were significantly lower, whereas FasL expression significantly higher in endometrioid adenocarcinoma than in normal endormetrium (7.88∓1.05 vs 19.25∓3.03, P<0.05; 12.95∓2.25 vs 7.51∓1.14, P<0.05).
CONCLUSIONIncreased apoptosis of the TIDCs and abnormal expression of Fas/FasL in TIDCs in endometrioid adenocarcinoma may lead to tumor immune escape.
