Three Cases of Reversible Agranulocytosis after Treatment with Lamotrigine.
- Author:
Yong Min AHN
1
;
Kunjong KIM
;
Yong Sik KIM
Author Information
- Publication Type:Case Report
- Keywords: Lamotrigine; Agranulocytosis; Bipolar disorder
- MeSH: Agranulocytosis*; Bipolar Disorder; Clozapine; Depression; Humans; Psychotropic Drugs; United States Food and Drug Administration
- From:Psychiatry Investigation 2008;5(2):121-123
- CountryRepublic of Korea
- Language:English
- Abstract: Several psychotropic drugs, including clozapine, are known to cause agranulocytosis and this may lead to a fatal condition. Lamotrigine is an anticonvulsant that the Food and Drug Administration (FDA) has approved for the depression of bipolar disorder. A few cases of lamotrigine-induced agranulocytosis have been previously reported on, but the pathophysiology and clinical manifestations are not yet known. This case series reports on 3 patients with different medical conditions who experienced agranulocytosis during treatment with lamotrigine. In these cases, the agranulocytosis occurred a few weeks after initiation of lamotrigine and it rapidly disappeared after discontinuation. We also discuss several characteristics of lamotrigine-induced agranulocytosis.
