Diverse expression of ER-α36, a novel variant of ER-α, in hippocampus and cortex of neonatal and adult rats.
- Author:
Yang LIU
1
,
2
;
liujing.dlrmc@hotmail.com.
;
Chen FANG
;
Ping ZOU
;
Yi-Ni MA
;
Dan-Nv HAN
;
Zhi-Hong JI
;
Xiao-Feng LIANG
;
Xin GUAN
;
Liang HUANG
;
Tian FENG
;
Yi-Ting WANG
;
Jing LIU
;
Wei ZOU
Author Information
1. College of Life Science, Liaoning Normal University, Dalian 116081, China; The Research Center of Developmental and Educational Psychology, Liaoning Normal University, Dalian 116029, China; Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Teacher's College, Dalian University, Dalian 116622, China; Medical College, Dalian University, Dalian 116622, China; School of Life Science, Fudan University, Shanghai 200433, China. E-mail: weizou60@
2. com; liujing.dlrmc@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Cerebral Cortex;
metabolism;
Estrogen Receptor alpha;
metabolism;
Hippocampus;
metabolism;
Pyramidal Cells;
metabolism;
Rats;
Rats, Sprague-Dawley;
Signal Transduction
- From:
Acta Physiologica Sinica
2013;65(3):263-268
- CountryChina
- Language:Chinese
-
Abstract:
ER-α36, a novel variant of ER-α, is expressed in breast, uterus, digestive tract, respiratory tract etc. The aim of the present study was to investigate the distribution and expression of ER-α36 in the central nervous system (CNS). Here, we comparatively analyzed the expression pattern of ER-α36 in the hippocampus and cortex of neonatal (1-day-old) and adult (12-week-old) Sprague-Dawley (SD) rats by using immunohistochemistry/immunocytochemistry analysis and Western blot. The results showed that ER-α36 was expressed both in hippocampus and cortex of adult rats, but mainly distributed in pyramidal neurons. ER-α36 was mainly located on the cytomembrane of hippocampal and cortical neurons from neonatal rats. Compared with the cortical neurons, the hippocampal neurons showed lower ER-α36 protein expression in the neonatal rats, but exhibited higher level of ER-α36 in the adult rats. Furthermore, the adult rats showed higher levels of ER-α36 expression in both hippocampus and cortex compared with the neonatal rats. These results suggest that ER-α36 might be involved in the regulation of membrane-initiated estrogen signaling throughout the postnatal development of diverse brain regions, and thus will be a potential target for the treatment of degenerative diseases in nervous system.
