Relationship between SNP rs10774671 on OAS-1 gene and spontaneous HBeAg seroconversion in chronic HBV infection
10.3760/cma.j.issn.1003-9279.2009.01.013
- VernacularTitle:OAS-1基因SNP rs10774671与慢性HBV感染者自发性HBeAg血清转换的关系
- Author:
Lu-Biao CHEN
1
;
Xiao-Mou PENG
;
Hong CAO
;
Yu-Feng ZHANG
;
Qi-Huan XU
;
Zhi-Liang GAO
Author Information
1. 中山大学附属第三医院
- Keywords:
Polymorphism,single nucleotide;
2',5'-oligoadenylate synthetnse;
Hepatitis B virus;
Alleles
- From:
Chinese Journal of Experimental and Clinical Virology
2009;23(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the SNP rs10774671 on OAS-1 gene and spontaneous HBeAg seroconversion in chronic HBV infection. Methods Blood samples were collected from 58 HBeAg positive, 68 anti-HBe positive patients with chronic HBV infection, and 72 normal control cases without HBV infection. Chromosomal DNA was extracted and OAS-1 gene was amplified. SNP genotyping was performed with the competitively differentiated polymerase chain reaction and enzyme immunoassay. Results In HBeAg positive group, frequencies of genotype GG plus GA and allele G were 31.0% and 16.4%. They were 48.5% and 29.4% in anti-HBe positive group, and 50.0% and 28.4% in normal control group respectively. Differences between HBeAg positive group and anti-HBe positive group or normal control group were statistically significant. But they weren't between anti-HBe positive group and normal control group. Conclusion Allele G on SNP rs10774671 of OAS-1 gene maybe benefits patients with chronic HBV infection to achieve spontaneous HBeAg seroconversion. Genotyping on this SNP may be predicting valuable for interferon therapy for chronic HBV infection.
