Clinical study on Yishen Qufeng Shengshi Recipe () for glomerular proteinuria patients: A randomized controlled trial.

Qin DAI; Pei-Qing ZHANG; Xiao-Qin WANG; Li-Fang NIE; Xiao-Jun FU; Wen PENG; Yi WANG; Jun LI; Yue-Ping BI; Xiu-Hua MI; Min YUAN; Li-Qun HE

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Clinical study on Yishen Qufeng Shengshi Recipe () for glomerular proteinuria patients: A randomized controlled trial.

Author: Qin DAI ¹ ; Pei-Qing ZHANG ² ; Xiao-Qin WANG ³ ; Li-Fang NIE ⁴ ; Xiao-Jun FU ⁵ ; Wen PENG ⁶ ; Yi WANG ⁷ ; Jun LI ⁸ ; Yue-Ping BI ⁹ ; Xiu-Hua MI ¹⁰ ; Min YUAN ¹¹ ; Li-Qun HE ^{12
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Author Information

1. Department of Nephrology, Central Hospital of Xuhui District, Shanghai, 200031, China.
2. Heilongjiang Academy of Traditional Chinese Medicine, Harbin, 150036, China.
3. Department of Nephrology, Hubei Provincial Traditional Chinese Medical Hospital, Wuhan, 430061, China.
4. Department of Nephrology, Xiyuan Hospital, Beijing, 100091, China.
5. Department of Nephrology, Jinhua Municipal Hospital of Traditional Chinese Medical, Jinhua, Zhejiang Province, 321017, China.
6. Department of Nephrology, Central Hospital of Shanghai Putuo District, Shanghai, 200062, China.
7. Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medical, Shanghai, 200437, China.
8. Department of Nephrology, The Fifth Affiliated Hospital of Zunyi Medical College (Zhuhai), Zhuhai, Guangdong Province, 519100, China.
9. Department of Traditional Chinese Medicine, Shanghai Yinhang Community Health Service Ceter, Shanghai, 200438, China.
10. Department of Nephrology, Shanghai Yangpu District Hospital of Traditional Chinese Medical, Shanghai, 200090, China.
11. Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
12. Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medical, Shanghai, 200021, China. heliqun59@
13. com.
Publication Type:Journal Article
Keywords: Chinese medicine; Yishen Qufeng Shengshi Recipe; glomerular proteinuria; losartan
From: Chinese journal of integrative medicine 2018;24(1):10-15
CountryChina
Language:English
Abstract:
OBJECTIVETo explore the therapeutic effect of Yishen Qufeng Shengshi Recipe (, YQSR) in patients with glomerular proteinuria METHODS: A total of 145 patients with glomerular proteinuria were selected and randomly assigned to the treatment group (108 cases) and the control group (37 cases) according to a random number table in a ratio of 3:1. All patients received conventional and symptomatic treatment. In addition, patients in the treatment and control groups were given YQSR (200 mL, twice per day, orally) and losartan (50 mg/d orally), respectively for 6 months. The 24-h urine protein quantity, blood urea nitrogen, and serum creatinine in the two groups were measured at multiple time points before and after treatment.
RESULTSAt the end of the study, 5 cases were lost to follow-up in the treatment group and 1 in the control group. Finally, the statistical data included 103 cases in the treatment group and 36 cases in the control group. The total effectiveness after 2, 4, and 6 months was 81.6% (84/103), 87.4% (90/103), and 92.2% (95/103), respectively, in the treatment group and 47.2% (17/36), 55.6% (20/36), and 61.1% (22/36), respectively, in the control group, with significant difference between the two groups (P<0.01 at all observation points). In the treatment group, the curative effect after 6 months was better than that after 2 months (P<0.05). The 24-h urine protein quantity was significantly lower in the treatment group at 3, 4, 5, and 6 months than that in the control group (P<0.05 or P<0.01, respectively) CONCLUSION: YQSR could significantly reduce the amount of glomerular proteinuria in the early stage.