Preparation of biodegradable and sustained release gel of tinidazole.
- Author:
Yuyue QIN
1
;
Lin LI
;
Wei LI
;
Minglong YUAN
;
Yanxin ZHU
;
Siyuan GUO
Author Information
1. College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China. yml@biochemzx.com
- Publication Type:Journal Article
- MeSH:
Delayed-Action Preparations;
Drug Carriers;
chemistry;
Gels;
Lactic Acid;
chemistry;
Polyesters;
Polymers;
chemistry;
Technology, Pharmaceutical;
methods;
Tinidazole;
administration & dosage
- From:
Journal of Biomedical Engineering
2007;24(1):87-90
- CountryChina
- Language:Chinese
-
Abstract:
The objective of this study was to prepare a biodegradable poly (DL-lactide) injectable gel of tinidazole. The formulation parameters evaluated in this study included polymer molecular weight, polymer concentration, solvent and drug loading, and orthogonal design was used to optimize the formulation. The preferable formulation was that 30% (w/w) poly(DL-lactide) (MW is 5 700) dissolved in 70% (w/w) N-methyl-2-pyrrolidone with 4%-6% (w/w) tinidazole.
