DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia.
10.1007/s11596-015-1434-1
- Author:
Ya-Nan LIU
1
,
2
;
Na ZHANG
;
Ying WU
;
Li YANG
;
Xiao-Yi DING
;
Jian-Feng ZHOU
;
Min XIAO
Author Information
1. Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, 13871288224@
2. com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Asian Continental Ancestry Group;
genetics;
China;
DNA (Cytosine-5-)-Methyltransferases;
genetics;
Female;
Humans;
Male;
Middle Aged;
Mutation;
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma;
genetics;
pathology;
Prognosis;
Survival Analysis;
Young Adult
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2015;35(3):337-342
- CountryChina
- Language:English
-
Abstract:
DNA methyl-transferase 3A (DNMT3A) mutation has recently been identified as an independent risk factor for patients with acute myeloid leukemia (AML). However, reports are scanty on its rate and subsequent impact on patients with acute lymphoblastic leukemia (ALL), especially in Chinese population. In this study, we investigated the incidence and prognostic implication of DNMT3A mutation in 57 Chinese adult ALL patients. A total of 3 (5.3%) T-ALL cases were found to have the DNMT3A R882H mutation, which was significantly greater than that found in B-ALL subtype (P=0.048). The patients aged between 40 and 60 years old had higher mutation rate than other age groups (P=0.042). Patients with DNMT3A mutation had shorter overall survival (OS) than their wild-type counterparts. Our study demonstrated that Chinese ALL patients might develop DNMT3A mutation, which exerts a negative impact on their prognosis. These findings might help in risk stratification and treatment choice for Chinese ALL patients.
