Distribution of variant genotypes of Fc gamma receptor IIIa in healthy Chinese population of Zhengzhou City.
- Author:
Jun WANG
1
;
Jianfei FENG
;
Li ZHANG
;
Yu HU
;
Bin LUAN
;
Weihai YUE
;
Hong WANG
;
Shaoxian ZHU
;
Yumei XU
Author Information
1. Department of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
European Continental Ancestry Group;
Genetic Variation;
Genotype;
Humans;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Receptors, IgG;
genetics
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2003;23(3):239-241
- CountryChina
- Language:English
-
Abstract:
To investigate the distribution of variant genotypes of Fc gamma receptor IIIa (Fc gamma R IIIa) in healthy Chinese population of Zhengzhou city, genomic DNA was extracted from peripheral blood of healthy donators. The genotypes of Fc gamma R IIIa-158 were determined by nested polymerase chain reaction (PCR) in 137 healthy people in Zhengzhou city. The results showed that frequencies of variant genotypes FF, VV and VF were 42.3%, 48.9% and 8.8% respectively. The distribution of Fc gamma R IIIa-158 in healthy Chinese population of Zhengzhou city was polymorphic and different from that of African Americans (AA) and Caucasian Americans (CA).
