Chemical constituents from roots of Illicium majus.
- Author:
Chang-Shan NIU
;
Ya-Dan WANG
;
Jing QU
;
Shi-Shan YU
;
Yong LI
;
Yun-Bao LIU
;
Shuang-Gang MA
;
Hai-Ning LV
;
Xia CHEN
;
Song XU
- Publication Type:Journal Article
- MeSH:
Drugs, Chinese Herbal;
analysis;
chemistry;
Illicium;
chemistry;
Organic Chemicals;
analysis;
chemistry;
Plant Roots;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(14):2689-2692
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds, including seven sesquiterpenes, two phenols and one phenylpropanoid, were isolated from the roots of Illicium majus by means of silica gel, ODS, Sephadex LH-20, and preparative HPLC. On analysis of MS and NMR spectroscopic data , their structures were established as cycloparviflorolide (1), cycloparvifloralone (2), tashironin (3), tashironin A (4), anislactone A(5), anislactone B (6), pseudomajucin (7), syringaldehyde (8), methyl-4-hydroxy-3, 5-dimethoxybenzoate (9), and (E)-3-methoxy-4,5-methylenedioxycinnamic alchol (10), respectively. Compounds 1-4 and 8-10 were first isolated from this plant. In the in vitro assays, at a concentration of 1.0 x 10(-5) mol x L(-1), compounds 5 and 6 were active against LPS induced NO production in microglia with a inhibition rate of 75.31% and 53.7%, respectively.
