Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94.

Author: Zhenfang ZHOU ¹ ; Xin WANG ¹ ; Hui ZHANG ² ; Jingya SUN ¹ ; Linghui ZHENG ² ; Hongchun LIU ¹ ; Jidong WANG ² ; Aijun SHEN ¹ ; Meiyu GENG ¹ ; Yuewei GUO ¹
Author Information

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2. Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China.
Publication Type:Journal Article
Keywords: Absolute configuration; Bacterium; Chromobacterium sp.; Chromopeptide A; Cytotoxicity; Depsipeptide; Marine-derived; Sediments
From: Acta Pharmaceutica Sinica B 2015;5(1):62-66
CountryChina
Language:English
Abstract: A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K α radiation (λ=0.71073 Å) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC50 values of 7.7, 7.0, and 16.5 nmol/L, respectively.