Expression of angiogenin-2 and VEGF in acute leukemia and its significance.
- Author:
Ping WANG
1
;
Lin-Hai RUAN
;
Xiao-Qiang ZHAO
Author Information
1. Department of Hematology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Adolescent;
Adult;
Aged;
Case-Control Studies;
Child;
Female;
Humans;
Leukemia, Myeloid, Acute;
metabolism;
pathology;
Male;
Middle Aged;
Neovascularization, Pathologic;
pathology;
Ribonuclease, Pancreatic;
metabolism;
Vascular Endothelial Growth Factor A;
metabolism;
Young Adult
- From:
Journal of Experimental Hematology
2010;18(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
The aim of study was to investigate the expression of angiogenin-2 (Ang-2) and vascular endothelial growth factor (VEGF) expression in acute leukemia (AL) and its significance in the angiogenesis and progress of AL. Serum levels of Ang-2 and VEGF in 24 de novo, 18 complete remitted (CR), 7 unremitted, 13 relapsed patients with AL were measured by enzyme-linked immunosorbent assay (ELISA), and compared with those of normal controls. The results showed that the serum levels of Ang-2 and VEGF in de novo, unremitted and relapsed patients were significantly higher than those in normal controls (p < 0.01). Compared with de novo group, the serum levels of Ang-2 and VEGF in CR patients decreased significantly, but showing no significant difference from those in normal controls (p > 0.05). In relapsed patients, the serum levels of Ang-2 and VEGF were obviously higher than those in unremitted and CR patients (p < 0.01). It is concluded that the expressions of Ang-2 and VEGF are closely related with occurrence and development of acute leukemia, the VEGF may regulate Ang-2 expression and promote angiogenesis and acute leukemia development. Preventing expressions of Ang-2 and VEGF may seem as targets for leukemia therapy in the future.
