Roles of Hypothalamic-Pituitary-Adrenal Axis and Hypothalamus-Pituitary-Ovary Axis in the Abnormal Endocrine Functions in Patients with Polycystic Ovary Syndrome.
10.3881/j.issn.1000-503X.2017.05.017
- VernacularTitle:下丘脑-垂体-肾上腺轴和下丘脑-垂体-卵巢轴在多囊卵巢综合征神经内分泌功能紊乱中的作用
- Author:
Fan WANG
1
;
Zheng-Hong ZHANG
1
;
Kai-Zhuan XIAO
1
;
Zheng-Chao WANG
1
Author Information
1. Provincial Key Laboratory for Developmental Biology and Neurosciences,College of Life Sciences,Fujian Normal University,Fuzhou 350007,China.
- Publication Type:Journal Article
- From:
Acta Academiae Medicinae Sinicae
2017;39(5):699-704
- CountryChina
- Language:English
-
Abstract:
Polycystic ovary syndrome(PCOS) is a common reproductive endocrine disease in women of childbearing age. While it can be affected by a variety of factors,its pathophysiology remains unclear. Its clinical features mainly include anovulation,hyperandrogenism,and hyperinsulinemia,which are closely related with abnormal neuroendocrine system. Hypothalamic-pituitary-gonadal axis(HPG) plays a crucial regulatory role in various life activities in mammals. In particular,hypothalamic-pituitary-adrenal(HPA) axis and hypothalamus-pituitary-ovary(HPO) axis can be abnormal in PCOS patients. The corresponding abnormalities include abnormal gonadotropin releasing hormone pulse frequency,increased luteinizing hormone/follicle-stimulating hormone ratio,and excessive excretion of adrenal and ovarian androgens. Meanwhile,insulin and leptin also play key roles in endocrine dysfunction in PCOS patients. This article systematically reviews the role of HPA axis and HPO axis in the neuroendocrine dysfunction in PCOS patients.
