Association between plasma adiponectin and small, dense low density lipoprotein in patients with coronary artery disease
10.3760/cma.j.issn.0253-3758.2012.09.007
- VernacularTitle:冠心病患者血浆脂联素水平及其基因多态性与小而致密的低密度脂蛋白胆固醇的关系
- Author:
Gang CHEN
1
;
Qin QIN
;
Yang LI
;
Bei REN
;
Ya-Ru LU
;
Lu KOU
;
Ning YANG
;
Jin-Ping FENG
;
Bing-Rang ZHAO
Author Information
1. 天津市胸科医院
- Keywords:
Coronary artery disease;
Adiponectin;
Lipoproteins,LDL;
Polymorphism,single nucleotide
- From:
Chinese Journal of Cardiology
2012;40(9):752-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the association between adiponectin and small dense low-density lipoprotein (sLDL-c) in coronary artery disease (CAD) patients.Furthermore,we sought to determine the association between single nucleotide polymorphisms (SNP) rs1501299 ( + 276G/T ), rs266729 (-11365C/G) and the incidence of CAD.Methods Consecutive subjects with chest discomfort were examined by coronary angiography and divided into non-CAD [ n =250,147 male,mean age (60.26 ±7.52) years] and CAD [n =267,153 male,mean age (60.79 ±9.63) years] groups.Blood samples were collected from all participants following an overnight fasting for at least 12 hours.Plasma adiponectin levels were measured by competitive enzyme-linked immunosorbent assay (ELISA).The serum levels of sLDL-C and oxidized low-density lipoprotein (ox-LDL) were determined by ELISA.Genotypes in rs1501299 and rs266729 of the adiponeetin were determined by polymerase chain reaetion ( PCR ).Results 1.The adiponectin levels were significantly lower [ ( 306.17 ± 74.52 ) mg/L vs.( 321.78 ± 86.28 ) mg/L ],whereas sLDL-C and ox-LDL levels were significantly higher [ ( 276.30 ± 45.55 ) ng/L vs.( 249.00 ±32.02) ng/L and (545.06 ± 115.46 ) μg/L vs.(497.74 ± 106.09 ) μg/L,P ＜ 0.05 ] in CAD group than non-CAD group.2.Adiponectin level was negatively associated with sLDL-C,whereas sLDL-C positively correlated with ox-LDL in all subjects.3.Genotype distribution and allele frequencies of rs1501299 and rs266729 were similar between CAD and non-CAD subjects and not related to the serum levels of adiponectin, sLDL-C and ox-LDL.Conclusions Reduced adiponectin and increased sLDL-C were independent risk factors for coronary artery disease.Genetic polymorphisms in rs1501299 and rs266729 were not linked with coronary artery disease.
